GenoLens — Genomic Variant Lookup

About

GenoLens is a browser extension for clinical geneticists, genetic counselors, and bioinformatics researchers. Highlight any gene symbol, variant ID (rsID), HPO term, or disease name on any webpage to instantly view multi-source genomic annotations in a compact tooltip — no tab-switching required.

**What you can look up:**
• Gene symbols (BRCA1, TP53, CYP2D6) → HGNC nomenclature, PanelApp diagnostic grades, UniProt protein function, PharmGKB drug interactions, Open Targets disease associations
• Variant IDs (rs121913527) → ClinVar pathogenicity with review stars, gnomAD population frequencies, Ensembl VEP functional predictions, AlphaMissense AI scores, LitVar2 publications
• HPO terms (HP:0001639) → Phenotype definitions and synonyms
• Disease names (Hypertrophic cardiomyopathy) → Associated genes with scores, relevant literature

**Key features:**
• Instant tooltip appears beside your text selection
• 15 trusted data sources queried in parallel
• Local caching for instant repeat lookups
• Colorblind-accessible confidence indicators
• Works on any webpage (PubMed, ClinVar, journals, EMRs)
• No account required — all core features are free

**Data sources:**
HGNC, PanelApp, ClinVar, gnomAD, Ensembl VEP, LitVar2, Open Targets, HPO, Europe PMC, UniProt, PharmGKB, ClinGen, DDG2P, Orphanet, AlphaMissense

**Privacy:**
• We do NOT read your browsing history
• We do NOT monitor page content
• We ONLY process the text you explicitly highlight
• No patient data should be entered — For Research Use Only

**Permissions explained:**
• "Read and change all your data on all websites" — Required to detect text selections and display the tooltip overlay on any webpage. We only activate when you highlight text.